Epidemiology of Esophageal Cancer in Japan and China
نویسندگان
چکیده
In preparation for a collaborative multidisciplinary study of the pathogenesis of esophageal cancer, the authors reviewed the published literature to identify similarities and differences between Japan and China in esophageal cancer epidemiology. Esophageal squamous cell carcinoma (ESCC) is the predominant histologic type, while the incidence of esophageal adenocarcinoma remains extremely low in both countries. Numerous epidemiologic studies in both countries show that alcohol consumption and cigarette smoking are contributing risk factors for ESCC. There are differences, however, in many aspects of esophageal cancer between Japan and China, including cancer burden, patterns of incidence and mortality, sex ratio of mortality, risk factor profiles, and genetic variants. Overall incidence and mortality rates are higher in China than in Japan, and variation in mortality and incidence patterns is greater in China than in Japan. During the study period (1987-2000), the decline in age-adjusted mortality rates was more apparent in China than in Japan. Risk factor profiles differed between high- and low-incidence areas within China, but not in Japan. The association of smoking and drinking with ESCC risk appears to be weaker in China than in Japan. Genome-wide association studies in China showed that variants in several chromosome regions conferred increased risk, but only genetic variants in alcohol-metabolizing genes were significantly associated with ESCC risk in Japan. A well-designed multidisciplinary epidemiologic study is needed to examine the role of diet and eating habits in ESCC risk.
منابع مشابه
The Trend of Esophageal Cancer Incidence in Iran
Introduction: Cancer is one of the main causes for mortality and morbidity in the world. Identifying epidemiology and the trend of esophageal cancer may be highly effective in related planning. The present study has been carried out with the aim of exploring the morbidity and trend of esophageal cancer in Iran. Methods: The present study is a type of repe...
متن کاملEpidemiology of Oral Cavity Cancers in a Country Located in the Esophageal Cancer Belt: A Case Control Study
Introduction: As one of the most common cancers among head and neck malignancies, cancer of the oral cavity probably has some variations in countries with a high prevalence of esophageal cancer. Materials and Methods: Patients with oral cavity cancer who were treated at two tertiary referral centers from January 1999 to January 2009 were included in this study. In addition to demographic data,...
متن کاملChanging Epidemiology of Esophageal Can-cer in Fars Province, Iran
Background: Esophageal carcinoma is one of the most lethal gastrointestinal (GI) malignant tumors worldwide. The disease is known to have a high incidence in northern Iran; however, its condition in the South is not much clear. Objective: In this retrospective study we investigated the epidemiology and time trends of esophageal carcinoma in Fars Province, South of Iran. Methods: In a retrospec...
متن کاملEpidemiology, etiology, and prevention of esophageal squamous cell carcinoma in China
Esophageal cancer is one of the most fatal diseases worldwide mainly because of its rapid progression and poor prognosis. Although the incidence of esophageal adenocarcinoma has markedly risen in North America and Europe in the past several decades, esophageal squamous cell carcinoma is still the predominant subtype of esophageal cancer, especially in China. It accounts for more than 90% of all...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 23 شماره
صفحات -
تاریخ انتشار 2013